Honeycomb lung seen in

Usual interstitial pneumonia

First things first: honeycomb lung is not actually a disease. Rather, it is the change in the structure of the lungs that is commonly seen in people afflicted with certain respiratory-related diseases, in particular during the end stages.

This pathological finding gets its name from the fact that the lung tissues end up resembling a honeycomb upon visual inspection. What makes such happen is the presence of small cyst-like structures that can be observed even without the aid of a microscope.

The said structures have diameters large enough to be seen by the naked eye, although they usually do not grow beyond 10 millimeters in diameter. The presence of honeycomb lungs can be observed when the person suffering from a respiratory-related disease undergoes x-ray or computed tomography CT scan. Specialists in lung care and diseases say that the presence of honeycomb lung is an indicative of poor prognosis.

In other words, it is unlikely for the patient to recover from the disease that has caused the honeycomb-like appearance of the lung tissues. The goal is to prevent the disease from worsening and causing further complications. One of the complications of honeycomb lung is pneumothorax. This condition is characterized by the presence of air in the space between the chest wall and the lungs themselves, something which is not quite normal. If not treated, the lungs could collapse. Pneumothorax is treated by relieving the pressure applied on the lungs by the air trapped between the chest wall and the lungs, thus allowing the lungs to expand during breathing.

Pulmonary hypertension is another complication that may arise from honeycomb lung. This is a kind of hypertension high blood pressure that has a profound effect on the arteries found in the lungs, as well as the right side of the heart.

Fatigue, dizziness, fainting spells, shortness of breath, chest pain and cyanosis bluish discoloration of the skin and lips are some of the symptoms of pulmonary hypertension. The initial and most noticeable symptoms of honeycomb lung are shortness of breath and dyspnea difficulty in breathing.

This does not really come as a surprise since the small cyst-like structures that characterize honeycomb lung significantly reduce lung capacity. These initial symptoms are noticeably progressive too, meaning they worsen overtime.

Nonproductive cough may be experienced by the individual with honeycomb lung. This particular symptom is similar to having dry cough wherein there is no sputum or mucus produced or expelled when coughing. As the respiratory-related disease behind honeycomb lung progresses, lung infection may take place which results in various additional symptoms.

Idiopathic pulmonary fibrosis is a disease characterized by thickening and stiffening of the tissues found deep within the lungs. This results in the formation of inflammatory cysts in various parts of the body, including the lungs. The presence of small growths in the lung tissue alters the structure of the lungs as well as affects the proper functioning of the said organs.

There are numerous other diseases that can lead to the development of honeycomb lungs. Some of them include radiation pneumonia, rheumatoid pneumonia, asbesotosis, aspiration and connective tissue disorders that may affect the lungs. In order to prevent the worsening of honeycomb lung, it is imperative to have the causative medical condition controlled.First things first: honeycomb lung is not actually a disease.

Rather, it is the change in the structure of the lungs that is commonly seen in people afflicted with certain respiratory-related diseases, in particular during the end stages.

This pathological finding gets its name from the fact that the lung tissues end up resembling a honeycomb upon visual inspection. What makes such happen is the presence of small cyst-like structures that can be observed even without the aid of a microscope.

The said structures have diameters large enough to be seen by the naked eye, although they usually do not grow beyond 10 millimeters in diameter. The presence of honeycomb lungs can be observed when the person suffering from a respiratory-related disease undergoes x-ray or computed tomography CT scan. Specialists in lung care and diseases say that the presence of honeycomb lung is an indicative of poor prognosis. In other words, it is unlikely for the patient to recover from the disease that has caused the honeycomb-like appearance of the lung tissues.

The goal is to prevent the disease from worsening and causing further complications. One of the complications of honeycomb lung is pneumothorax. This condition is characterized by the presence of air in the space between the chest wall and the lungs themselves, something which is not quite normal.

If not treated, the lungs could collapse. Pneumothorax is treated by relieving the pressure applied on the lungs by the air trapped between the chest wall and the lungs, thus allowing the lungs to expand during breathing. Pulmonary hypertension is another complication that may arise from honeycomb lung. This is a kind of hypertension high blood pressure that has a profound effect on the arteries found in the lungs, as well as the right side of the heart.

Fatigue, dizziness, fainting spells, shortness of breath, chest pain and cyanosis bluish discoloration of the skin and lips are some of the symptoms of pulmonary hypertension. The initial and most noticeable symptoms of honeycomb lung are shortness of breath and dyspnea difficulty in breathing.

This does not really come as a surprise since the small cyst-like structures that characterize honeycomb lung significantly reduce lung capacity. These initial symptoms are noticeably progressive too, meaning they worsen overtime.

Nonproductive cough may be experienced by the individual with honeycomb lung. This particular symptom is similar to having dry cough wherein there is no sputum or mucus produced or expelled when coughing. As the respiratory-related disease behind honeycomb lung progresses, lung infection may take place which results in various additional symptoms. Idiopathic pulmonary fibrosis is a disease characterized by thickening and stiffening of the tissues found deep within the lungs. This results in the formation of inflammatory cysts in various parts of the body, including the lungs.

The presence of small growths in the lung tissue alters the structure of the lungs as well as affects the proper functioning of the said organs. There are numerous other diseases that can lead to the development of honeycomb lungs. Some of them include radiation pneumonia, rheumatoid pneumonia, asbesotosis, aspiration and connective tissue disorders that may affect the lungs.

In order to prevent the worsening of honeycomb lung, it is imperative to have the causative medical condition controlled.Interstitial in-tur-STISH-ul lung disease describes a large group of disorders, most of which cause progressive scarring of lung tissue. The scarring associated with interstitial lung disease eventually affects your ability to breathe and get enough oxygen into your bloodstream. Interstitial lung disease can be caused by long-term exposure to hazardous materials, such as asbestos.

Some types of autoimmune diseases, such as rheumatoid arthritis, also can cause interstitial lung disease. In some cases, however, the causes remain unknown. Once lung scarring occurs, it's generally irreversible. Medications may slow the damage of interstitial lung disease, but many people never regain full use of their lungs. Lung transplant is an option for some people who have interstitial lung disease.

Interstitial lung disease care at Mayo Clinic. By the time symptoms appear, irreversible lung damage has often already occurred.

Nevertheless, it's important to see your doctor at the first sign of breathing problems. Many conditions other than interstitial lung disease can affect your lungs, and getting an early and accurate diagnosis is important for proper treatment.

In your lungs, the main airways bronchi branch off into smaller and smaller passageways — the smallest, called bronchioles, lead to tiny air sacs alveoli. Interstitial lung disease seems to occur when an injury to your lungs triggers an abnormal healing response. Ordinarily, your body generates just the right amount of tissue to repair damage. But in interstitial lung disease, the repair process goes awry and the tissue around the air sacs alveoli becomes scarred and thickened. This makes it more difficult for oxygen to pass into your bloodstream.

Interstitial lung disease can be triggered by many different things — including airborne toxins in the workplace, drugs and some types of medical treatments. In most cases, the causes are unknown. Long-term exposure to a number of toxins and pollutants can damage your lungs. These may include:. Some people who receive radiation therapy for lung or breast cancer show signs of lung damage months or sometimes years after the initial treatment.

The list of substances and conditions that can lead to interstitial lung disease is long.

honeycomb lung seen in

Even so, in some cases, the causes are never found. Disorders without a known cause are grouped together under the label of idiopathic interstitial pneumonias, the most common and deadly of which is idiopathic pulmonary fibrosis. Mayo Clinic does not endorse companies or products.

honeycomb lung seen in

Advertising revenue supports our not-for-profit mission. Don't delay your care at Mayo Clinic Schedule your appointment now for safe in-person care. This content does not have an English version. This content does not have an Arabic version.

Request an appointment. Overview Interstitial in-tur-STISH-ul lung disease describes a large group of disorders, most of which cause progressive scarring of lung tissue. Request an Appointment at Mayo Clinic. Bronchioles and alveoli in the lungs Open pop-up dialog box Close. Bronchioles and alveoli in the lungs In your lungs, the main airways bronchi branch off into smaller and smaller passageways — the smallest, called bronchioles, lead to tiny air sacs alveoli.

Share on: Facebook Twitter. Show references Raghu G, et al. An update of the clinical practice guideline. Goldman L, et al.

honeycomb lung seen in

Interstitial lung disease.Usual interstitial pneumonia UIP is a form of lung disease characterized by progressive scarring of both lungs. UIP is thus classified as a form of interstitial lung disease.

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The term "usual" refers to the fact that UIP is the most common form of interstitial fibrosis. A term previously used for UIP in the British literature is cryptogenic fibrosing alveolitis CFAa term that has fallen out of favor since the basic underlying pathology is now thought to be fibrosis, not inflammation. The term usual interstitial pneumonitis UIP has also often been used, but again, the -itis part of that name may overemphasize inflammation.

The typical symptoms of UIP are progressive shortness of breath and cough for a period of months. In some patients, UIP is diagnosed only when a more acute disease supervenes and brings the patient to medical attention. The cause of the scarring in UIP may be known less commonly or unknown more commonly. Since the medical term for conditions of unknown cause is "idiopathic", the clinical term for UIP of unknown cause is idiopathic pulmonary fibrosis IPF.

UIP may be diagnosed by a radiologist using computed tomography CT scan of the chest, or by a pathologist using tissue obtained by a lung biopsy. Radiologically, the main feature required for a confident diagnosis of UIP is honeycomb change in the periphery and the lower portions bases of the lungs. There may be superimposed CT features such as mild ground-glass opacityreticular pattern and pulmonary ossification.

The histologic hallmarks of UIP, as seen in lung tissue under a microscope by a pathologist, are interstitial fibrosis in a "patchwork pattern", honeycomb change and fibroblast foci see images below. Appearance of usual interstitial pneumonia UIP in a surgical lung biopsy at low magnification. The tissue is stained with hematoxylin purple dye and eosin pink dye to make it visible.

The pink areas in this picture represent lung fibrosis collagen stains pink. Note the "patchwork" quilt-like pattern of the fibrosis. Appearance of honeycomb change in a surgical lung biopsy at low magnification. The dilated spaces seen here are filled with mucin. Hematoxylin-eosin stain, low magnification. A fibroblast focus in a surgical lung biopsy of UIP.

Hematoxylin-eosin stain, high magnification.

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The white space to the left is an airspace. The pale area to the right is a fibroblast focus. It is an area of active fibroblast proliferation within the interstitium of the lung. The differential diagnosis includes other types of lung disease that cause similar symptoms and show similar abnormalities on chest radiographs. Some of these diseases cause fibrosis, scarring or honeycomb change. The most common considerations include:. Oxygen therapy may assist with daily living.

In case of idiopathic pulmonary fibrosiscertain medications like nintedanib and pirfenidone can help slow the progression. Regardless of cause, UIP is relentlessly progressive, usually leading to respiratory failure and death without a lung transplant. The outlook for long-term survival is poor. In most studies, the median survival is 3 to 4 years.

UIP, as a term, first appeared in the pathology literature. It was coined by Averill Abraham Liebow. From Wikipedia, the free encyclopedia. There is interstitial thickening, architectural distortion, honeycombing and bronchiectasis. Specialty Respirology Usual interstitial pneumonia UIP is a form of lung disease characterized by progressive scarring of both lungs.

General principles and recommendations". European Respiratory Review.Honeycombing is a CT imaging descriptor referring to clustered cystic air spaces between mm in diameter, but occasionally as large as 2. They can be subdivided into:. Honeycombing consists of enlarged air spaces with thick fibrotic walls lined by bronchiolar epithelium and often filled with mucin and inflammatory cells 6. Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys.

Honeycombing

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Idiopathic Pulmonary Fibrosis - Restrictive Lung Disease - Pulmonology

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URL of Article. Article information. System: Chest. Section: Signs. Figure 1: photograph - Bee honeycomb Figure 1: photograph - Bee honeycomb.

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